踝臂指数与急性冠脉综合征患者预后关系的Meta分析

Ankle Brachial Index and the Prognosis of Patients with Acute Coronary Syndrome:A Meta-Analysis

目的:评价踝臂指数(ABI)与急性冠脉综合征(ACS)患者预后之间的关系。方法:从Cochrane Database of System Reviews、PUBMED、EMBASE等数据库中检索关于ABI与ACS的随机对照试验,同时筛检纳入研究的参考文献。对符合标准的研究通过I2统计量进行异质性检验,采用固定效应模型进行Meta分析,得到相对危险度(RR)值及其95%可信区间(CI)。结果:根据纳入和排除标准,共纳入4篇文献,总随访人数5320例,其中低ABI组与正常ABI组比较发生全因死亡事件的RR=2.39,95%CI(1.50～3.82),发生心源性死亡事件的RR=3.00,95%CI(1.98～4.54),再发ACS事件的RR=1.61,95%CI(1.26～2.05),发生卒中事件的RR=3.88,95%CI(1.85～8.10)。结论:在已发生ACS患者中,低ABI者更容易发生心脑血管恶性事件。

Objective：To evaluate the association between ankle brachial index（ABI） and the prognosis of patients with acute coronary syndrome.Method：Computer search cochrane database of system reviews,PUBMED,EMBASE,to find the randomized controlled trial about ankle brachial index and the prognosis of patients with acute coronary syndrome.Screen the reference of these articles,case control studies which accord with the standard was selected.Heterogeneity was analyzed with I2,risk ratio（RR） and its 95% confidence interval（CI） by fixed effect model of meta-analyse.Results：A total 4 studies were included according to inclusion and exclusion criteria,there were 5320 cases in all.Compared with the normal ABI group,in low ABI group,the RR of all caused death ratio was 2.39,95%CI（1.50～3.82）;RR of cardiac mortality was 3.00,95%CI（1.98～4.54）;RR of of ACS was 1.61,95%CI（1.26～2.05） and RR of stroke was 3.88,95%CI（1.85～8.10）.Conclusion：Low ankle brachial index is associated with higher risk of cardiac death,stroke or cardiovascular events.