依托咪酯分次注射在青少年首次无抽搐电休克(MECT)治疗中的应用

The Application of Etomidate Fractional Injection in First Modified Electroconvulsive Therapy (MECT) in Adolescents

目的观察依托咪酯分次注射较一次注射在青少年首次无抽搐电休克治疗中对运动发作的影响及安全性和不良反应的评估。方法将140例青少年患者随机分为研究组(n=70)依托咪酯分次注射组,对照组(n=70)依托咪酯一次注射组。观察记录首次发作后发作时间、抽搐指数、平均动脉压、呼吸意识恢复时间等指标以及相关不良反应出现的次数。结果研究组的发作时间平均为(75.46±26.45)s,显著少于对照组(96.53±38.49)s,(P<0.05)。研究组中躁动谵妄、严重头痛、高热的发生率明显低于对照组。其余各项指标两组无明显差异(P>0.05)。结论较之传统方法依托咪酯分次注射安全、有效、不良反应少。

Objective To observe the effects of etomidate fractional injection or an injection in first electroconvulsive therapy in adolescents.Methods 140 cases of adolescent patients were randomly divided into study group（n=70） and control group（n=70）.In study group,patients received fractional injection in MECT.But in control group,patients received an injection in MECT.All the subjects were evaluated with the first attack,tetany index,mean arterial blood pressure,the time of breathing and consciousness recovery and related adverse reaction occurred during the treatment.Results The time of first attack was（75.46±26.45）s in study group,it was lower than that in control group（P0.05）.The incidences of agitated delirium,severe headache,high fever in study group was significantly lower than in control group.Conclusion Etomidate fractional injection is a safety and effective method in first MECT in adolescents.