STX6和p53在食管癌组织中的表达及相互关系的研究

Expression of STX6 and its correlation with p53 in esophageal carcinoma

目的探讨突触融合蛋白6(syntaxin 6,STX6)和p53蛋白在食管癌组织中的表达及临床意义。方法应用免疫组织化学方法检测46例食管癌患者的肿瘤组织和癌旁食管组织中STX6和p53蛋白的表达情况,并进行统计分析。结果食管癌组织中STX6和p53蛋白的表达较癌旁食管组织明显上调,阳性率分别为54.3%和63.0%;相关分析发现STX6和p53蛋白的表达量与患者的性别、年龄无显著相关(P>0.05),但与肿瘤的分化程度以及淋巴结转移显著相关(P<0.05);STX6和p53在食管癌组织中的表达呈显著正相关(r=0.45,P<0.05)。结论 STX6作为p53家族的共同作用靶点,在食管癌发生、发展的过程中与p53起到了协同作用。

Objective To investigate the expression and clinical significance of syntaxin 6（STX6） and p53 in esophageal carcinoma.Methods Immunohistochemical staining was carried out to determine the expression of STX6 and p53 in esophageal carcinoma and normal esophageal tissue from 46 patients.Results The positive incidences of STX6 and p53 expression in esophageal carcinoma tissues were 54.3% and 63.0%,respectively.Association analysis revealed that the high expression of STX6 and p53 had negative correlations with age and gender（P0.05）.However,significant correlations with tumor differentiation and lymph node metastasis were identified（P0.05）.The over expression of STX6 strongly correlated with positive expression of p53 in esophageal carcinoma（r=0.45,P0.05）.Conclusion STX6,as the novel p53 family target gene,might play an important role in esophageal carcinoma,together with p53.