升清胶囊对阻塞性黄疸患者微创术后细胞免疫功能的改善作用

The improving cellular immune function of Shengqing capsule on post-microresecting obstructive jaundice patients

目的研究升清胶囊对阻塞性黄疸患者微创术后细胞免疫功能的改善作用。方法将符合纳入标准的51例患者,采用简单随机方法分为研究组(升清胶囊组)、对照组(胆维他组)和空白组(常规治疗组),每组17例。术后空白组常规处理,不服用利胆药物;对照组除常规处理外,于术后第1天起口服胆维他;研究组除常规处理外,于术后第1天开始口服中药升清胶囊。术后第1、7天分别检测患者免疫指标CD3、CD4、sIL-2R、IL-10、TNF及TB。采用单因素方差分析的统计学方法对实验数据做统计处理。结果研究组、对照组与空白组术后第1天CD3、CD4、sIL-2R、TNF、IL-10值比较均无统计学差异(P>0.05);术后第7天比较均有统计学差异(P<0.05)。术后第7天CD3、CD4、sIL-2R值与术后第1天比较,研究组比对照组均增高(P<0.05);对照组比空白组均增高(P<0.05);研究组比空白组均增高(P<0.05)。术后第7天TNF值与术后第1天比较,研究组较对照组无显著性降低(P>0.05);对照组比空白组降低(P<0.05);研究组比空白组降低(P<0.05)。术后第7天IL-10值与术后第1天比较,研究组比对照组降低(P<0.05);对照组比空白组无显著性降低(P>0.05);研究组比空白组降低(P<0.05)。术后第1、7天各组间TB值比较均无统计学差异(P>0.05)。结论升清胶囊能更有效地加快阻塞性黄疸患者微创术后免疫功能的恢复,较不服用利胆药物及服用胆维他者有明显优势。

Objective To study improving cellular immune function of Shengqing capsule on post-microresectingobstructive jaundice patients. Methods Fifty-one patients who accepted were randomly divided into research group （Shengqing capsule）, control group （anethole trithione） and blank group （conventional therapy）, 17 patients in each group. The blank group was treated without choleretic preparation after operation, the control group was treated with conventional therapy add anethole trithione and the research group conventional therapy with Shengqing capsule since 1^st day of postoperative, respectively. CD3 （cluster of differentiation antigen 3）, CD4 （cluster of differentiation antigen 4）, sIL-2R （expression of serum soluble interleukin-2 receptor）, IL-10（interleukin-10）, TNF （tumor necrosis factor）, TB （total bilirubin） in 1^st and 7^th day postoperative were determined. Experimental data was tested by One-way ANOVA analysis. Results Vales of CD3, CD4, sIL-2R, TNF and IL-IO in postoperative 1^st day between the three groups showed no statistical difference（P 〉 0.05）; Vales in postoperative 7^th day showed statistical difference（P 〈 0.05）. Compared with control group, values of CD3 , CD4, sIL-2R between 1^st day and postoperative 7^th day in research group had statistical significance and to be significantly increased（P〈 0.05）, compared with blank group, those valueswere significantly increased iu control group and had statistical significance（P〈 0.05）, and compared with blank group, so did in research group（P〈 0.05）. Compared with control group, values of TNF between postoperative 1^st dav and 7^th day in research group showed no statistical significance and to be decreased slightly（P〉 0.05）, compared wilh blank group, those values were significantly decreased in control group and had slatistieal signifieanee（P 〈 0.05）, and compared with blank group, so did in research group（P〈 0.05）. Compared with control group, values of IL-10 between postoperative 1^st day and 7^th day in experimental group showed statistical significance and to he significantly decreased （P 〈 0.05）, compared with blank group, those values were decreased slightly in control group aud had no statistical significance（P〉 0.05）, and compared with blank grolap, those values were significantly decreased and showed slalis- tieal sicnifieanee（P〈 0.05）. Vales of TB in 1^st day and 7^th day between the three groups showed no statistical difference （P 〉 0.05）. Conelusion Shengqing capsule can speed up the recovery of immune functions on post-mieroresecting obstructive jaundice patients, h has obvious advantage.