绝经期女性脑梗死患者血清雌二醇及同型半胱氨酸的相关性分析

Correlation Analysis of Serum Estradiol and Homocysteine of Postmenopausal Women with Cerebral Infarction

目的:研究绝经期女性脑梗死患者血清中雌二醇(E2)、同型半胱氨酸(Hcy)变化,探讨两者相关性及对缺血性脑血管疾病的可能影响机制。方法:254例女性患者,根据是否绝经和是否脑梗死,分为绝经期脑梗死组(A组)60例、绝经期非脑梗死组(B组)63例、非绝经期脑梗死组(C组)66例及非绝经期非脑梗死组(D组)65例4组,分别抽取患者空腹静脉血,测定血清E2及Hcy水平。结果:血清E2水平A组低于其他3组,有统计学意义(P<0.05);C组低于D组,有统计学意义(P<0.05)。血清Hcy水平A组高于其他3组,有统计学意义(P<0.05),C组高于D组,有统计学意义(P<0.05)。血清E2与Hcy水平相关性分析显示呈明显负相关。结论:E2水平降低可导致血Hcy水平的升高,可能为绝经期女性脑梗死发生的机制之一。

Objective：To investigate the changes of serum estradiol（E2） and homocysteine（Hcy） in post-menopausal women with cerebral infarction,and to explore the correlation of E2 and Hcy and their effect on outcome of patients with ischemic cerebral-vascular disease.Methods： Two hundred and fifty-four female patients were divided into menopause cerebral infarction group,menopausal non-cerebral infarction,non-menopausal cerebral infarction and non-menopausal non-cerebral infarction groups.The venous blood samples were obtained from patients and the E2 and homocysteine（Hcy） levels in the serum were determined.Results：The Serum estradiol levels in menopausal cerebral infarction group were significantly decreased compared with those in the other three groups（P0.05）.The Serum estradiol levels in the non menopausal cerebral infarction group were significantly lower than those in the non menopausal non cerebral infarction group（P0.05）.The serum Hcy levels in cases in the menopausal cerebral infarction group were significantly increased relative to those in the other three groups（P0.05）.The Hcy levels in the non menopausal cerebral infarction group was significantly higher than that in the non menopausal non cerebral infarction group（P0.05）.The Serum estradiol levels were correlated negatively with homocysteine level in the postmenopausal women with cerebral infarction.Conclusion：Reduced estradiol levels correlate with elevated blood homocysteine levels,which may be involved in the pathological process of postmenopausal women with cerebral infarction.