深圳市福田区2009-2010年疑似预防接种异常反应监测分析

Analysis on the surveillance of adverse events following immunization in Futian district of Shenzhen,2009-2010

目的分析深圳市福田区疑似预防接种异常反应(AEFI)的发生特征。方法通过国家网络信息系统收集AEFI个案资料,采用描述性方法对相关指标进行分析。结果2009-2010年报告AEFI 394例,其中≤2岁儿童占65.74%,男女性别比为1.28∶1。接种后1 d内发生占79.44%。AFFI分类诊断中,一般反应占59.14%,异常反应占22.59%,偶合症占18.27%。临床诊断前3位为:发热、红肿、硬结,过敏性皮疹,无菌性脓肿,分别占57.11%、19.54%、5.08%。394例AEFI预后良好,未出现后遗症或死亡病例。发生AEFI前3位的疫苗为麻疹减毒活疫苗、全细胞百白破疫苗、甲型流感(裂解)疫苗,分别为69例(17.51%)、63例(15.99%)、57例(14.47%)。不同疫苗AEFI报告发生率在28.53/100万剂～1 495.00/100万剂。结论辖区AEFI监测敏感性和质量都较之前有明显的提高,各项监测指标均达到了国家方案要求,但AEFI报告发生率与WHO报道的预期发生率还有一定差距,说明监测工作仍有待提高。

Objective The study is to analyze the occurrence features of adverse event following immunization（AEFI） in Futian district of Shenzhen.Methods The AEFI data of 2009-2010 were collected through the China Information System for Disease Control and Prevention.The descriptive methodology was used in the study.Results 394 AEFI cases of 2009-2010 were reported.65.74% cases were ≤2 years old.The ratio of male and female was 1.28∶1.79.44% cases happened within ld after vaccination.In the classification of AEFI cases,59.14% cases were common vaccine reactions,14.65% were rare vaccine reactions and 18.27% cases were coincidental event.The first three clinical manifestations were fever,redness and nodule（57.11%）,allergic eruption（19.54%）and aseptic obscess（5.08%）.394 AEFI cases were all with good prognosis,with no sequelae and died.The first three vaccines were measles attenuated live vaccine（17.51%）,DTwP（15.99%）,InfV-Sp（14.47%）.The estimate reported incidence of different vaccines were 28.53～1 495.00 per million doses.Conclusion Sensitivity and quality of AEFI monitor in Futian district were improved greatly in 2009-2010,and all the monitoring indicators had reach the standard,but the estimate reported incidence of vaccines was still lower than WHO′s expected incidence,so the work still needs to be strengthened.