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BDNF及其信号通路在酒精成瘾和毒性中的作用 被引量:2

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摘要 酒精摄入以及由此产生的相关问题已经是人类社会面临的一个重要的公共卫生问题,但是关于其发生的机制和相关应对措施一直没有取得很好的进展。近年来,BDNF(Brain Derived Neurotrophic Factor)信号通路被作为药物成瘾研究的靶标,在酒精成瘾和毒性方面也得到了很多研究。本文综述几年来酒精成瘾机制研究取得的一些进展,详细介绍BDNF及其信号通路在酒精成瘾和毒性方面的作用,以及BDNF基因多态性跟酒精依赖和酒精相关特征的关联性,期待能够对国内相关领域的研究人员提供参考。
出处 《神经解剖学杂志》 CAS CSCD 北大核心 2012年第3期325-329,共5页 Chinese Journal of Neuroanatomy
基金 国家自然科学基金(30960156) 国家973课题项目(2011CB944200)
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