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宫颈鳞癌Ⅲ期同步放化疗后巩固化疗疗效分析

Analysis of the Efficacy of Consolidation Chemotherapy after Concurrent Chemoradiation for the Treatment of Stage III Cervical Squamous Cell Carcinoma
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摘要 [目的]探讨宫颈鳞癌Ⅲ期患者同步放化疗后巩固化疗的疗效和毒副作用.[方法]将2007年1月至2008年6月收治的84例宫颈鳞癌Ⅲ期同步放化疗的患者随机分为试验组（40例）和对照组（44例）,试验组患者在同步化疗后接受2个疗程的巩固化疗.对照组未行巩固化疗.观察比较两组患者的3年生存率和毒副反应.[结果]试验组和对照组相比,3年生存率（86.5%和72.7%）和无进展生存率（82.0%和70.3%）均有所提高,差异有统计学意义（P＜0.05）.试验组Ⅲ～Ⅳ度骨髓抑制发生率为27%.[结论]宫颈鳞癌Ⅲ期同步放化疗后巩固化疗对生存率有益,但骨髓抑制较为严重. [Objective]To explore the efficacy and toxicity of consolidation chemotherapy after concurrent chemoradiotherapy for the treatment of stage Ⅲ cervical squamous cell carcinoma. [Methods] Totally 84 patients with stage Ⅲ cervical squamous cell carcinoma receiving concurrent chemoradiotherapy admitted to our hospital from Jan. 2007 to June 2008 were randomly divided into experiment group（ n = 40） and control group（ n = 40）. The 3-year survival rate and toxicity of two groups were compared. [Results]Compared with control group, the 3-year overall survival （OS） and progression-free survival（PFS） rate of consolidation group increased（86. 5% vs 72. 7%, 82. 0% vs 70.3 % ）, and there was significant difference（ P %0.05）. However, the incidence of grade Ⅲ OR Ⅳ of bone marrow suppression in consolidation group was higher than that in control group. [Conclusion]Consolidation chemotherapy after concurrent chemoradiation for the treatment of stage Ⅲ cervical squamous cell carcinoma is benefit for the survival rate, but has more serious bone marrow suppression.
作者 唐洁 王蕾
机构地区 湖南省肿瘤医院妇瘤一科
出处 《医学临床研究》 CAS 2012年第4期610-613,共4页 Journal of Clinical Research
基金 湖南省自然科学基金面上项目 （编号09JJ5012）
关键词 癌 鳞状细胞 宫颈肿瘤/放射疗法 宫颈肿瘤/药物疗法 Carcinoma,squamous cell cervix neoplasms/RA cervix neoplasms/DT
分类号 R737.33 [医药卫生—肿瘤]
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参考文献14

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二级参考文献10

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医学临床研究
2012年 第4期

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