摘要
[目的]探讨屋尘螨特异性免疫治疗对哮喘患儿血清屋尘螨和粉尘螨特异性IgG4(sIgG4)水平的影响.[方法]40例接受屋尘螨特异性免疫治疗12月的哮喘患儿,抽取其治疗前后血清,检测治疗前后血清屋尘螨及粉尘螨的特异性IgG(sIgE)和sIgG4.[结果]脱敏治疗后的患者血清中屋尘螨和粉尘螨特异性sIgE无明显变化,sIgG4抗体水平均有显著上升(P〈0.01).[结论]使用屋尘螨脱敏疫苗治疗所产生的sIgG4抗体能同时识别屋尘螨和粉尘螨两种抗原,从而使机体产生对这两种致敏原的免疫保护作用.
[Objective] To explore the effect of dermatophagoides pteronyssinus(Der p) specific immunotherapy (SIT) on specific IgG4 of Der p and dematophagoides farinae(Der f) in asthma patients. [Methods]Serum samples were collected from 40 pediatric patients with asthma receiving Der P SIT for 12 months before and after treatment. Serum sIgE and sIgG4 of Der p and Der f were detected before and after treatment. [Results] After desensitization treatment, serum slgE of Der p and Der f had no obvious change, but sIgG4 increased significantly( P d0.01). [Conclusion] IgG4 produced by desensitization treatment with Der p vaccine can recognize both Der p and Der f antigens simultaneously, which makes the body having immunoprotection effect on these two allergens.
出处
《医学临床研究》
CAS
2012年第4期627-629,共3页
Journal of Clinical Research