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口服药物吸收的细胞模型研究进展 被引量：1

Advance on cell model for oral drug absorption
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摘要 多种细胞模型如最常用的Caco-2和MDCK细胞,以及新近开发的MDCK-MDR1、M细胞、药物溶出/Caco-2细胞组合、HT-29和TC7细胞等均可用于口服药物吸收的评价,但也存在一定的局限性。本文综述各类细胞模型的特点及其应用等相关研究进展。 Among various cell models as tools in oral drug absorption research,the most commonly used models are Caco-2 and MDCK cell including resent developed cell models,MDCK-MDR1,M cell,dissolution/Caco-2 system,HT-29 and TC7 cell.However,these cell models have some limitations.This review describes the specificity and application of various cell models.
作者 江雪 奚泉 周建平 金方
机构地区 中国药科大学药剂学教研室 中国医药工业研究总院上海医药工业研究院
出处 《世界临床药物》 CAS 2012年第5期292-297,共6页 World Clinical Drug
关键词 口服药物 细胞模型 CACO-2细胞 MDCK细胞 M细胞 药物溶出/Caco-2细胞 oral drug cell model Caco-2 cell MDCK cell M cell dissolution/Caco-2 system
分类号 R945 [医药卫生—微生物与生化药学]
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世界临床药物
2012年 第5期

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