大籽獐牙菜的化学成分研究(Ⅰ)

Studies on the Chemical Constituents of Swertia macrosperma(I)

对采自云南新平县的大籽獐牙菜脂溶性部分进行了化学成分研究,采用各种柱色谱法进行分离纯化得到11个化合物,通过波谱数据分析鉴定它们的结构为:1,7-二羟基-3-甲氧基口山酮(1),1,2,6-三甲氧基-8-羟基口山酮(2),1,7-二羟基-3,8-二甲氧基口山酮(3)、齐墩果酸(4),马钱苷酸(5),獐牙菜苷(6),7-甲氧基獐牙菜苷(7),2'-O-(3-羟基苯甲酰基)-獐牙菜苷(8),3-O-葡萄糖基-1,7,8-三甲氧基口山酮(9),2-对羟基苯基乙醇(10),3,7,4',4″-四羟基-3',3″-二甲氧基-2,5-环氧木脂素(11),其中化合物11为首次从该属植物中分离得到.

Study on chemical constituents of Swertia macrosperma. Eleven compounds, 1,7 - dihydroxy - 3 - me- thoxyxanthone （ 1 ）, 1,2,6 - trimethoxy - 8 - hydroxyxanthone （2）, 1,7 - dihydroxy - 3,8 - dimethoxyxanthone （3）, oleanic acid （4）, loganic acid （5）, sweroside （6）, 7 - methoxysweroside （7）, 2＇ - 0 - （ 3 - hydroxy- benzoyl） - sweroside （8）, 3 - 0 - glucopyranosyl - 1,7,8 - trihydroxyxanthone （9）, 2 - （4 - hydroxyphenyl） eth- anol （ 10）, and 3,7,4＇,4＂ - tetrahyroxy - 3＇, 3＂ - dimethoxy - 2,5 - epoxylignan （ 11 ）, were isolated and purified by silica gel, RP - 18, and sephadex LH - 20 column chromatograhies. Their structures were determined by spec- troscopic methods, compound 11 was isolated from the genus for the first time.