特发性眼眶炎性假瘤的治疗进展

Clinical treatment of idiopathic orbital inflammatory pseudotumor

特发性眼眶炎性假瘤（IOIP）是一种较为常见的眼眶疾病，表现为多种慢性炎性细胞浸润，并伴有不同程度的纤维结缔组织增生，其病因及发病机制不明。目前，该病的临床治疗主要包括药物治疗、放射治疗和手术治疗3个方面；其中，药物治疗最为常用，主要包括糖皮质激素类药物和免疫抑制剂两类。尽管近年来应用包括烷化剂、抗代谢药物和单克隆抗体等在内的多种免疫抑制剂的病例报道逐渐增多，但是迄今为止糖皮质激素类药物仍是公认的首选治疗方法。就IOIP的各种治疗方法及其进展进行综述。

Idiopathic orbital inflammatory pseudotumor （IOIP） is a common ophthalmic disease with uncertain etiology and pathogenesis. It charactarized by chronic inflammatory cell infiltration and connective tissue proliferation. At present,its clinical treatments mainly include pharmacotherapy,radiation therapy and surgery, and the primary treating drugs include glucocorticosteroids and immunosuppressive agents. The mainstay of therapy is systemic glucocorticosteroids, although there is an increasing trend toward the use of alkylating agents, antimetabolites, monoc｜onal antibodies and other immunosuppressive agents. The progress in clinical treatment of IOIP was reviewed.