脊髓损伤与骨质疏松相关性研究进展

Research progress in the correlation between spinal cord injury and osteoporosis

目的骨质疏松是脊髓损伤的并发症之一,会严重影响患者的生活质量。流行病学研究发现脊髓损伤会显著增加骨质疏松和骨折的发生率,应该引起康复专家的广泛重视。本文主要对脊髓损伤与骨质疏松的相关性进行综述,着重探讨SCI后骨质疏松的发生机制。各项研究发现,脊髓损伤主要影响椎骨以外的松质骨,表现为骨量的减少和骨结构的改变;骨的拉伸力、弯曲应力等力学性能也显著降低。SCI后骨质疏松的发生与瘫痪持续的时间、机械刺激、痉挛状态、年龄等因素相关。SCI后骨在生化、神经调节、基因表达等方面都发生了特异性的改变,但都无明确结论,因此关于SCI与骨质疏松相关性的研究有待于进一步探讨。

Objective Osteoporosis is one of the complications of spinal cord injury （SCI） and can severely decrease the life quality of the patients. The epidemiology studies find that SCI can increase the prevalence of osteoporosis and bone fractures and should be concerned by rehabilitation experts. This paper mainly reviewes the correlation between osteoporosis and SCI. Many studies have shown that SC1 damage spongy bones other than vertebrae, showing as reduced bone mass and changed bone structure and decreased mechanical properties. SOl-related osteoporosis is related to the duration of paralysis, the mechanical stimulation, the influence of spasticity, and age etc. All the biochemistry, neuroregulation, and gene expression of bone change after SCI, however, with no confirmed conclusion. So the studies for the correlation between SCI and osteoporosis need to be explored.