手性配体诱导的不对称频哪醇偶联反应研究进展

PROGRESS IN ASYMMETRIC PINACOL COUPLING REACTION INDUCED BY CHIRAL LIGANDS

邻二醇是重要的合成中间体,也是不对称合成中常用的手性辅剂,手性配体或手性分子合成中间体。频哪醇偶联反应是合成邻二醇类结构最快捷的方法,不对称频哪醇偶联反应是通过人工创造的手性环境来实现频哪醇偶联反应中的立体选择性。本研究综述了近年来不对称频哪醇偶联反应研究中取得的重要进展,并对这一领域的发展提出了展望。

Vicinal diols is an important category of synthetic intermediates,and also can act as chiral auxiliaries,ligands or synthetic intermediates for chiral molecules in asymmetric synthesis.Pinacol coupling reaction is a direct method for vicinal diols generation.Stereoselectivities in asymmetric pinacol coupling can be realized via chiral environments created by manual methods.This review summarized the recent progress in asymmetric pinacol coupling reaction,and corresponding prospects in this field have also been put forward.