补肾运脾针刺治疗饮水型氟中毒:随机对照研究

Drinking-water type fluorosis treated with acupuncture of reinforcing kidney and activating spleen:a randomized controlled trial

目的:观察以补肾运脾为原则的针刺治疗对饮水型氟中毒患者尿氟排泄及疼痛的影响。方法:采用随机对照单盲试验,将72例患者随机分为观察组和对照组,每组36例。观察组针刺脾俞、肾俞、关元、足三里等穴位,每周3次;对照组口服碳酸钙D3片,每次600mg,每日2次。疗程均2个月,比较两组患者治疗前后尿氟含量及疼痛视觉模拟评分(VAS)的变化。结果:治疗后观察组尿氟明显升高(P<0.01),且明显高于对照组[(11.06±4.54)mg/L vs(8.30±4.14)mg/L,P<0.05];治疗后两组VAS评分均显著降低(均P<0.01),且观察组明显低于对照组(1.93±1.30vs 3.47±2.29,P<0.01)。结论:以补肾运脾为原则的针刺治疗对促进饮水型氟中毒患者尿氟排泄及缓解疼痛效果显著,且效果优于口服碳酸钙D3。

Objective To observe the impacts of acupuncture of reinforcing kidney and activating spleen on the excretion of urinary fluoride and pain of the patients with drinking-water type fluorosis.Methods The rando-mized controlled and single-blind trial was adopted.Seventy-two cases were randomized into an observation group and a control group,36 cases in each one.In the observation group,acupuncture was applied at Pishu（BL 20）,Shenshu（BL 23）,Guanyuan（CV 4）,Zusanli（ST 36）,etc.,three treatments a week.In the control group,the Calcium Carbonate D3 tablets were prescribed for oral administration,600 mg each time,twice a day.The duration of treatment was 2 months.The changes of the content of urinary fluoride and pain score（by VAS） before and after treatment between two groups were compared.Results The urinary fluoride excretion was increased obviously after treatment in the observation group（P0.01）,which was superior apparently to that in the control group [（11.06±4.54）mg/L vs（8.30±4.14）mg/L,P0.05].After treatment,VAS score was reduced significantly in either group（both P0.01）.The result in the observation group was lower remarkably than that in the control group（1.93±1.30 vs 3.47±2.29,P0.01）.Conclusion Acupuncture achieves the significant efficacy on the promotion of urinary fluoride excretion and pain relieving of the patients with drinking-water type fluorosis in light of reinforcing kidney and activating spleen,which is superior to the oral administration of the Calcium Carbonate D3 tablets.