浒苔绿藻精对四氧嘧啶致糖尿病小鼠糖脂代谢的影响

Study on Glucolipid Metabolism of Chlorella Growth Factor in Alloxan-induced Diabetic Mice

目的:研究浒苔绿藻精(CGF)对四氧嘧啶致糖尿病小鼠糖脂代谢的调节作用。方法:采用四氧嘧啶(0.24g/kg)腹腔注射建立糖尿病小鼠模型,CGF以200mg/kg、400mg/kg、800mg/kg 3个剂量分别灌胃给药,空白对照组和模型组均以蒸馏水(0.2mL/10g)灌胃,连续28d。测定小鼠的日采食量、日饮水量和血清总胆固醇(TC)超氧化物歧化酶(SOD)和脏器指数。结果:各CGF组小鼠日采食量和日饮水量均逐渐减少,模型组则反之;CGF高、中剂量组28d空腹血糖值较0d有所降低,但无统计学意义(P>0.05);而模型组灌胃28d的空腹血糖值较0d显著升高(P<0.05);CGF高剂量组小鼠血清TC含量较模型组显著下降(P>0.05);各CGF组血清SOD活性均较模型组显著升高(P<0.05);CGF高剂量组小鼠的胸腺指数较模型组显著升高(P<0.05),各剂量组与模型组间的脾脏指数相比没有显著差异(P>0.05),但随着剂量的增大,脾脏指数呈逐渐升高的趋势。结论:CGF对四氧嘧啶致糖尿病小鼠糖脂代谢有一定的调节作用。

【Objective】 To study the effect of Chlorella Growth Factor on glucolipid metabolism in diabetic mice.【Method】Alloxan-induced diabetic mice were randomly divided into 4 groups according to the level of blood glucose.Totally 3 groups were given the CGF 200mg/kg,400mg/kg,800mg/kg respectively for 28 d.Record the daily food intake and water quantity,measure the TC and SOD in the serum and the viscera index of liver and kidney.【Result】Compared with the diabetic model group,CGF could reduce the daily food intake and water quantity.The middle and high does of CGF could lower the level of blood glucose（P0.05）.All doses of CGF could decrease serum TC remarkably（P0.05）,while increased the level of SOD（P0.05）.The high does of CGF could increase the viscera index of liver.【Conclusion】CGF had certain regulatory role in glucolipid metabolism to the diabetic mice induced by alloxan.