CDKAL1基因rs7754860位点G<C多态性与2型糖尿病易感关系的Meta分析

Meta-analysis on CDKAL1 gene rs7754860 single neucleotide polymorphisms and type 2 diabetes mellitus susceptibility

背景:遗传学研究显示2型糖尿病可能存在遗传易感性,但研究结论存在一定的差异。目的:探讨CDKAL1(细胞周期素依赖激酶5调节亚单位相关蛋白1类似物1)基因rs7754860位点G<C单核苷酸多态性与2型糖尿病易感性的关系。方法:检索EMBASE(1974/2011-05)、PubMed(1966/2011-05)、中国期刊全文数据库(1994/2011-05)、中国生物医学文献数据库(1978/2011-05)中CDKAL1基因rs7754860位点G<C单核苷酸多态性与2型糖尿病易感性关系的病例-对照研究或队列研究。以病例组和对照组CDKAL1基因rs7754860G<C等位基因分布的比值比为效应指标,并根据异质性检验结果选择随机效应模型或固定效应模型对比值比进行合并。结果与结论:共查到符合要求的文献9篇,病例组19103例,对照组22560例。分析结果显示:CDKAL1基因rs7754860位点变异纯合子个体(CC)患2型糖尿病的风险与野生纯合子(GG)相比明显增高(OR=1.51,95%CI:1.24～1.84,P<0.01);显性模式下,CDKAL1基因rs7754860位点变异个体(CC+CG)患2型糖尿病的风险与野生纯合子(GG)相比增高不明显(OR=1.22,95%CI:0.95～1.56,P=0.12);隐性模式下,CDKAL1基因rs7754860位点变异纯合子个体(CC)患2型糖尿病的风险较野生型(GG+GC)明显增高(OR=1.61,95%CI:1.41～1.83,P<0.01)。说明CDKAL1基因rs7754860位点G<C多态性与2型糖尿病易感性存在关联,携带C等位基因的个体为2型糖尿病的易感人群。

BACKGROUND： The pathogenesis of type 2 diabetes is unclear, and genetic studies have shown that there may be genetic predisposition, but the results are not consistent with each other. OBJECTIVE： To evaluate the relationship between cyclin-dependent kinase 5 regulatory subunit-associated protein l-like 1 （CDKAL1） gene rs7754860 G〈C single neucleotide polymorphisms and type 2 diabetes mellitus susceptibility. METHODS： By searching EMBSE （1974/2011-05）, PubMed （1966/2011-05）, CNKI （1994/2011-05） and CBM （1978/2011-05）, we collected studies about CDKAL1 gene rs7754860 G〈C single neucleotide polymorphisms and type 2 diabetes mellitus susceptibility. The odds ratios （OR） of variant allele of CDKAL1 gene rs7754860 was calculated by using Review Manager 5.0 software. RESULTS AND CONCLUSION： A total of 19 03 cases and 22 560 controls were included in nine case-control studies. The risk for type 2 diabetes mellitus was higher in the CC group compared with GG group （OR=1.51, 95% confidence interval （C/）： 1.24-1.84, P 〈 0.01 ）; For the dominant genetic model, the risk for type 2 diabetes mellitus had no significant difference between the CC＋GG group and GG group （OR=1.22, 95%C1： 0.95-1.56, P=0.12）. For the recessive genetic model, the risk for type 2 diabetes mellitus in the CC group was significantly increased as compared with the GC＋GG group （OR=1.61,95%C1：1.41-1.83 P 〈 0.01）. CDKAL1 gene rs7754860 C〈G single neucleotide polymorphisms has close relationship with type 2 diabetes mellitus susceptibility. People with C allele are susceptible to type 2 diabetes mellitus.