光动力疗法联合相关治疗研究进展

Advances in photodynamic therapy combined with related therapy for tumor

目的:总结可增强光动力疗法(PDT)抗肿瘤免疫效应的相关治疗研究进展。方法:应用PubMed和CNKI数据库,以"光动力疗法、肿瘤、免疫疗法、靶向光敏剂、肿瘤疫苗和免疫抑制"等为关键词,检索2000-01-2011-08的相关文献。纳入标准:1)PDT联合的免疫疗法;2)靶向光敏剂;3)PDT光照剂量;4)PDT免疫抑制效应;5)PDT肿瘤疫苗。排除重复研究与本研究无关的文献,符合分析的文献32篇。结果:PDT处理后对宿主免疫系统的影响极为复杂,既能促进抗肿瘤免疫,在某些情况下又能抑制免疫;PDT联合免疫佐剂、细胞因子或免疫细胞可有效增强PDT抗肿瘤免疫反应;疫抑制效应具有条件性,可通过制备靶向光敏剂、调节光照剂量和去除负向调节性免疫效应分子及调节性T细胞等多种途径减弱甚至去除这种生物效应;PDT处理后肿瘤细胞裂解物具有免疫刺激作用,可用作肿瘤疫苗。结论:联合免疫疗法或其他方法来增强PDT抗肿瘤免疫效应、拮抗免疫抑制效应,可显著提高PDT抗肿瘤疗效。

OBJECTIVE： To sum up the articles correlated with the advances in related therapy that can enhance the immunity effect of photodynamic therapy for cancer. METHODS： ＂photodynamic therapy, tumor,immunotherapy, targeted photosensitizers, tumor vaccine,immunosuppression＂ were searched as key words in PubMed and CNKI database from 2000-01 to 2011-08. Including standards： 1） immunotherapy combined with PDT; 2） targeted photosensitizers ; 3） PDT light does; 4） the immunosuppression of PDT; 5） PDT tumor vaccines. The articles that were repetitive studies and had no relations with the study were excluded, 32 articles were included in references finally. RESULTS： PDT can not only provoke the host immune response, but also suppress under some circumstances; PDT combined with immunoadjuvant, cytokines and immunocytes can strength host anti-tumor immunity; Immunesuppression of PDT is conditional, through applying targeted photosensitizers, adjusting light dose and removing the negative immune effectors and regulatory T ceils can weakened and even got rid of the biological effect; Treated with PDT, the tumour cells cracking products had the function of immunologic enhancement,can be used as tumor vaccines. CONCLUSION： Combined with immunotherapy and other treatments to strength host anti-tumor immunity and antagonize PDT immunosuppression, can significantly improve the anti-tumor effect of PDT.