长春西汀联合泼尼松治疗原发性肾病综合征疗效观察

Clinical study of vinpocetine combined with prednisone in the treatment of primary nephrotic syndrome

目的观察长春西汀联合泼尼松治疗原发性肾病综合征的临床疗效。方法选取原发性肾病综合征患者62例，随机分为观察组和对照组。对照组采用泼尼松及常规治疗，观察组在对照组治疗基础上给予长春西汀注射液静脉滴注，两组疗程均为3周。观察两组患者临床改善情况。结果观察组总有效率（83．9％）明显高于对照组总有效率（61．3％）（P〈0．05），两组治疗后血浆白蛋白、24h尿蛋白定量与本组治疗前比较有统计学差异（P〈0．05），观察组较对照组改善更显著（P〈0．05），观察组尿素氮、血肌酐、活化部分凝血活酶时间、纤维蛋白原、D-二聚体较治疗前明显改善（P〈0．05），与对照组相比有统计学差异（P〈0．05）。结论长春西汀联合泼尼松治疗原发性肾病综合征安全有效，能有效改善血液高凝状态。

Objective To explore the curative efficacy and safety of vinpocetine combined with prednisone on patients with primary nephrotic syndrome （PNS）. Methods Sixty-two patients with PNS were randomly divided into the observation group and control group. Both groups were treated with full dosage of prednisone and conventional therapy, and the observation group was added with vin- pocetine, 30 rag/day, for 3 weeks. The clinical symptoms in the two groups were observed. The changes of serum albumin（Alb）, blood urea nitrogen（BUN）, serum creatinine（SCr）, activated partial thrombo- plastin time（APTT）, fibrinogen（Fib）, D-dimer （D-D） and urinary total protein （UTP） in two groups were respectively compared before and after treatment. Results At 3rd week after treatment,total effective rate in observation group（83.9%） was significantly higher than in control group（61.3%, P〈0. 05）. The levels of Alb were increased significantly and UTP decreased significantly in two groups （P 〈0. 05）, and more significantly in observation group than in control group （P〈0. 05）. Meanwhile the levels of BUN,SCr,APTT,Fib and D-D were ameliorated greatly （P〈0.05） as compared with those before treatment in observation group, and these changes were also remarkably different between observation group and control group （P〈0. 05）. Conclusions On the top of routine treatment,vinpocetine combined with prednisone are effective and safe in treatment of PNS with hypercoagulability.