摘要
乙型肝炎病毒（HBV）感染的检测主要包括血清学和病毒学两部分,血清学检测指标主要有病毒表达产物及其抗原抗体系统,即血清HBsAg、抗-HBs、HBeAg、抗-HBe和抗-HBc五项标志物,病毒学检测指标主要有血清HBV DNA和肝组织中共价闭合环状DNA（cccDNA）等。HBV DNA是反映HBV复制活动和传染性最直接的指标,在确定慢性HBV感染自然史、监测抗病毒药物疗效以及评估急慢性乙型肝炎（乙肝）
Hepatitis B virus（HBV） DNA level is the most reliable index that directly reflects the viral replication activity,which is the key factor in determining the natural history of chronic HBV infection,monitoring the effect of antiviral therapy and assessing the prognosis of acute and chronic HBV infection.Although currently available assays for quantifying serum HBV DNA demonstrated high sensitivity and accuracy,the relatively high costs have limited the widespread routine application.Assays for quantitative detection of HBsAg and HBeAg showed advantages of being convenient,rapid and economic.Studies have shown that serum HBsAg levels reflect the replication levels of HBV DNA,but vary upon phases of HBV infection,HBeAg status and HBV genotypes.In addition,the serum HBeAg titers in HBeAg-positive patients are positively correlated with HBV DNA levels in serum,but vary upon the ages of the patients.
出处
《中国病毒病杂志》
CAS
2012年第3期173-178,共6页
Chinese Journal of Viral Diseases
基金
国家"十一五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2008ZX10002-001)
