高龄中风患者骨代谢指标变化及相关因素分析

Analysis of the changes and influence factors of senile patients with the stroke in biochemical markers of bone metabolism

目的:探讨中风高龄患者血清N端骨钙素(NMID)、血清甲状旁腺素(PTH)、血清I型胶原羟基端前肽(β-CTX)变化及相关影响因素分析。方法:采用电化学发光免疫分析法检测120例中风高龄患者骨代谢指标以及血清总蛋白、白蛋白,并记录患者饮食方式、卧床时间、感染次数以及其他相关临床资料。结果:PTH的中位数为44.53 pg/mL(11.93～87.46pg/mL),与饮食方式,卧床时间,感染次数等呈明显相关(P<0.05);β-CTX的中位数为0.355ng/mL(0.06～0.99ng/mL),与年龄(正相关)、卧床时间呈负相关(P<0.05);对于血清NMID,存在性别差异,男性中位数为13.04ng/mL(3.63～37.43 ng/mL),而女性中位数为17.80ng/mL(6.81～50.80 ng/mL),所有患者NMID水平与血清白蛋白水平呈正相关(P<0.05)。另外,女性血清NMID水平与卧床时间呈明显负相关(P<0.05)。结论:中风高龄患者,饮食方式、卧床时间、反复感染等相关因素影响其骨代谢过程。

Aim：To analysis the changes and influence factors of senile patients with stroke in the biochemical markers of bone metabolism（Serum NMID,PTH,β-CTX）.Methods： we measured the serum biochemical markers for senile patients（120 cases） by electro chemiluminescence immunoassay（ECLIA）,and recorded the patients＇ diet style,bedridden time,infection times,and other Clinical data.Results： The median of PTH is 44.53 pg/mL（11.93~87.46 pg/mL）,with a correlation to diet style,bedridden time,infection times（P0.05）;the median of β-CTX is 0.355 ng/mL（0.06~0.99 ng/mL）,with a positive correlation to the age,and negative correlation to bedridden time（P0.05）.Due to gender difference for NMID,the median of male is 13.04 ng/mL（3.63~37.43 ng/mL）,while the median of female is 17.80 ng/mL（6.81~50.80 ng/mL）,with a positive correlation to serum NMID of all patients（P0.05）.Any other,for female,there is a significant negative correlation between the serum NMID and the bedridden time.Conclusion：There are some correlations between the biochemical markers of bone metabolism and the diet style,bedridden time,recurrent infection to the senile patients with stroke.