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氨甲环酸在体外循环中对炎性反应的作用 被引量：1

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摘要 目的分析氨甲环酸在体外循环(CPB)中对炎性反应方面作用,进一步探讨氨甲环酸在CPB中的应用。方法选取60例瓣膜置换术患者,年龄35～65岁,心功能Ⅱ～Ⅲ级。将他们随机分成2组,其中试验组于体外循环过程中静脉注射氨甲环酸。2组分别于CPB转机前、复温5min和返回ICU5min抽取动脉血,并分别测定TNF-α、IL-6、sICAM-1的含量。结果 2组患者的年龄、体重、手术时间、主动脉阻断时间进行组间比较,差异无统计学意义(P>0.05)。试验组患者TNF-α、IL-6、sICAM-1在体外循环前与对照组差异无统计学意义(P>0.05),体外循环复温5min、返回ICU5min2组间差异有统计学意义(P<0.05)。结论 AMCA可以有效抑制体外循环引起的全身炎性反应。
作者 刘传彬 葛圣林 张成鑫
机构地区 安徽医科大学第一附属医院
出处 《河北医药》 CAS 2012年第9期1337-1338,共2页 Hebei Medical Journal
关键词 氨甲环酸 体外循环 炎性反应
分类号 R364.5 [医药卫生—病理学]
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参考文献9

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二级参考文献13

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共引文献25

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河北医药
2012年 第9期

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