甲钴胺联合凯时治疗糖尿病周围神经病变效果观察

Effect of Mecobalamin combined with Alprostadil in the treatment of diabetic peripheral neuropathy

目的:观察甲钴胺联合凯时治疗糖尿病周围神经病变的临床效果,以评价其临床价值。方法:糖尿病周围神经病变患者82例随机分为治疗组和对照组各41例,治疗组给予甲钴胺联合凯时治疗;对照组给予维生素B12治疗。比较两组治疗前、后Semmes-Weinstein单丝(5.07/10g)检查、MNSI(Michigan Neuropathy Screening Instrument),神经传导速度结果。结果:治疗组治疗后Semmes-Weinstein单丝(5.07/10g)检查、MNSI(Michigan Neuropathy Screening Instrument),神经传导速度结果均较治疗前明显改善,且优于对照组,差异均有统计学意义。结论:甲钴胺联合凯时治疗糖尿病周围神经病变疗效显著,值得临床推广应用。

Objective：To observe the effect of Mecobalamin combined with Alprostadil in the treatment of diabetic peripheral neuropathy and to evaluate its clinical value.Methods：82 patients with diabetic peripheral neuropathy were randomly divided into treatment group and control group averagely.The treatment group was administered Mecobalamin combined with Alprostadil（PGE1） for four weeks,at the same time,the control group received vitamin B12.Semmes-Weinstein monofilament exam,Michigan Neuropathy Screening Instrument（MNSI） and nerve conduction velocity results in the two groups were compared before and after treatment.Results：Semmes-Weinstein monofilament exam,Michigan Neuropathy Screening Instrument（MNSI） and nerve conduction velocity results after 4-week treatment were all improved in treatment group than those before treatment and those in control group.Conclusion：Mecobalamin combined with Alprostadil in the treatment of diabetic peripheral neuropathy is effective and deserves to the clinical popularization and application.