舍曲林合并喹硫平治疗伴有精神病性症状强迫症的对照研究

Sertraline combined with Quetiapine in the treatment of obsessive-compulsive disorder with psychotic symptoms

目的:探讨舍曲林合并喹硫平治疗伴有精神病性症状强迫症的疗效及安全性。方法:将60例伴有精神病性症状的强迫症患者根据随机数字表分为两组,观察组给予舍曲林合并喹硫平治疗,对照组给予舍曲林治疗,应用耶鲁-布朗强迫量表(Yale-Brown obsessive-compulsive scale,YBOCS)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)、简明精神病评定量表(brief psychiatric rating scale,BPRS)评定疗效,用副反应量表(treatment emergent symptom scale,TESS)评定治疗过程中的不良反应。疗程8周。结果:治疗后两组的Y-BOCS、HAMA、HAMD、BPRS评分均低于治疗前(P<0.05),且两组在8周末的Y-BOCS、HAMA,HAMD、BPRS评分差异均有统计学意义(P<0.05)。两组不良反应比较差异无显著性(P>0.05)。结论:舍曲林合并喹硫平治疗伴有精神病性症状的强迫症效果优于单用舍曲林治疗。

Objective：To explore the effect and safety of sertraline combined with quetiapine in the treatment of obsessive-compulsive disorder（OCD） with psychotic symptoms.Methods：A total of 60 OCD patients with psychotic symptoms were assigned to observed group（n=30） and control group（n=30） according to random digits table for the treatment of 8 weeks.Observed group was given sertraline in addition to quetiapine,and control group was sertraline alone.The clinical effect was assessed with Y-ROCS,HAMA,HAMD and BPRS at the end of 8th week.The adverse reaction was evaluated by TESS.Results：Compared with pretreatment,scores of the Y-BOCS,HAMA,HAMD and BPRS decreased in two groups（P0.05）.The scores difference of the Y-BOCS,HAMA,HAMD and BPRS had statistical significance at the end of 8th week between the two groups（P0.05）.There was no significant difference in side effects between the two groups（P0.05）.Conclusion：Sertraline combined with quetiiapine is more effective than sertraline in the treatment of OCD with psychotic symptoms.