摘要
目的探讨糖尿病前期和糖尿病的相关因素。方法根据ADA 2003年分类标准,对糖尿病前期和糖尿病相关因素进行Logistic回归分析。总共纳入204名对象,正常血糖66名,糖尿病前期100例,糖尿病患者38例。结果 3种不同的血糖状态在TG、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)、血清总免疫球蛋白E(IgE)和C-RP的分布差异均具有统计学意义(P<0.05或P<0.01);多变量Logistic回归分析结果表明,IR与IS是糖尿病前期及糖尿病的危险因子(P<0.05)。结论 HOMA-IR与HOMA-β是公认的糖尿病的危险因子。
Objective To explore the risk fact6rs related to prediabetes and diabetes under ADA 2003 classification criteria. Methods A total of 204 subjects aged 55 to 75 years were analyzed in the current study. One-way ANOVA, chi-square test and non-parametric test and logistic regression analysis were used for data analysis. Normal blood glucose was defined as FPG〈5. 6 mmol/L and 2 hPG〈7. 8 mmol/L, prediabetes was defined as 5. 6 mmol/L≤FPG〈7. 0 mmol/L or 7. 8 mmol/L≤2 hPG〈1l. 0 mmol/L, diabetes mellitus was defined as FPG≥7. 0 mmol/L and 2 hPG≥11. 0 mmol/L. Results （1） There was significant difference in TG （P〈0. 05）, HOMA-IR （P〈0. 01）, HOMA-β （ P〈0. 01）, IgE （P〈0. 05） and C-RP（P〈0. 05） among three different blood glucose groups. （2）Multi-variate logistic regression analysis showed that insulin resistance （IR） and insulin sensitivity were significant risk factors of prediabetes and diabetes （P〈0. 05, P〈0. 05）. Conclusions Insulin resistance and insulin sensitivity are risk factors for diabetes, large-scale epidemiological studies are needed for further identification of the. results.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2012年第6期421-423,共3页
Chinese Journal of Diabetes
基金
湖州市科技局科技攻关项目(2008GS09)
浙江省卫生厅医药项目(2008B178)
浙江省教育厅科研项目(20070470)
关键词
糖尿病前期
糖尿病
胰岛素抵抗
胰岛素敏感性
Prediabetes
Diabetes mellitus
Insulin resistance
Insulin sensitivity
