ATP-红外生物效应技术治疗重度外阴阴道假丝酵母菌病疗效观察

Observation on the curative effect of ATP-infrared biological effect technique in treatment of severe vulvovaginal candidiasis

目的:观察ATP-红外生物效应技术对重度外阴阴道假丝酵母病(SVVC)患者的治疗效果。方法:采用前瞻性随机对照研究方法,共有153例SVVC患者完成观察。治疗组77例,采用ATP-红外生物效应治疗技术,1次/天,共2次;治疗后阴道内放置硝酸咪康唑栓400 mg/天,共6天。对照组76例,阴道内放置硝酸咪康唑栓400 mg/天,共6天。开始治疗后,患者每天记录自觉症状及不良反应,停药后3天、30天复查,进行疗效评价。结果:①治疗组治疗起效时间为(0.7±0.6)h,对照组为(19.3±8.8)h,差异具有统计学意义(P<0.01)。治疗后第1～4天,治疗组患者症状自评分下降幅度明显大于对照组,差异具有统计学意义(P<0.01)。②停药后3天,治疗组和对照组临床有效率分别为90.91%和73.68%,真菌学转阴率分别为96.10%和85.53%,总有效率分别为89.61%和69.74%,差异均具有统计学意义(P<0.05)。③停药后30天,治疗组和对照组临床有效率分别为94.80%和68.42%,真菌学转阴率分别为96.10%和82.89%,总有效率分别为92.21%和64.47%,差异均具有统计学意义(P<0.01)。结论:ATP-红外生物效应技术可快速缓解SVVC患者的自觉症状,有效提高其近期及远期疗效,使患者的生活质量提升,是治疗SVVC的有效方法。

Objective： To observe the curative effect of ATP- infrared biological effect technique in treatment of patients with severe vulvovaginal candidiasis （SVVC） . Methods ： One hundred and fifty - three patients with SVVC were observed by prospective random-zed controlled trial. Seventy - seven cases in treatment group were treated with ATP - infrared biological effect technique, once a day for two times, then the cases were treated with vaginal application of miconazole nitrate suppository, 400 mg per day for six days. Seventy - six cases in control group were treated with vaginal application of miconazole nitrate suppository, 400 mg per day for six days. The cases were asked to record the subjective symptoms and adverse reactions every day after the start of treatment ; the cases in the two groups were reexamined at 3 and 30 days after drug withdrawal; evaluation of curative effect was carried out. Results： The onset times in treatment group and control group were （0. 7 ± 0. 6 ） hours and （19. 3 ± 8.8 ） hours, respectively, there was statistically significant difference （P 〈 0. 01 ） . From the first day to the fourth day after treatment, the decrease amplitude of score of subjective symptoms in treatment group was statistically significant larger than that in control group （P 〈0.01 ） . On the third day after treatment, the clinical effective rates in treatment group and control group were 90. 91% and 73.68%, respectively; the negative conversion rates of fnngal examination in treatment group and control group were 96. 10% and 85.53%, respectively; the total effective rates in treatment group and control group were 89. 61% and 69. 74% , respectively, there was statistically significant difference in the above - mentioned indexes between the two groups （ P 〈 0. 05 ） . On the thirtieth day after treatment, the clinical effective rates in treatment group and control group were 94. 80% and 68.42%, respectively; the negative conversion rates of fungal examination in treatment group and control group were 96. 10% and 82. 89%, respectively; the total effective rates in treatment group and control group were 92. 21% and 64. 47%, respectively, there was statistically significant difference in the above - mentioned indexes between the two Woups （P 〈 0.01 ） . Conclusion： ATP- infrared biological effect technique can relieve the subjective symptoms of the patients with SVVC rapidly, improve shortterm curative effect and longterm curative effect, and elevate the quality of life of the patients, which is an effective method to cure SVVC.