中国人内皮型一氧化氮合酶基因G894T多态性与脑梗死相关性的Meta分析

The association of endothelial nitric oxide synthase gene G894T polymorphism with cerebral infarction in Chinese population:a meta-analysis

目的综合评价中国人内皮型一氧化氮合酶基因G894T(Glu298Asp)多态性与脑梗死的关系。方法搜集国内外公开发表的有关中国人内皮型一氧化氮合酶基因G894T多态性与脑梗死关系的研究文献,剔除不符合要求的文献,应用Meta分析软件RevMan5.1,对各研究结果进行异质性检验及数据合并,应用RevMan5.1和Stata11.0评估发表偏倚。结果共有11篇文献纳入Meta分析,累计病例组1768例,对照组1818例。合并基因型(GT+TT)/GG的OR值为1.46,95%CI为1.24～1.73(P<0.00001),合并基因型TT/GG的OR值为2.18,95%CI为1.32～3.61(P=0.002),合并基因型GT/GG的OR值为1.41,95%CI 1.18～1.67(P=0.0001),合并等位基因T/G的OR值为1.65,95%CI 1.28～2.12(P=0.0001)。结论中国人内皮型一氧化氮合酶基因G894T(Glu298Asp)多态性与脑梗死的发病具有相关性。携带基因型TT、GT及等位基因T可增加患脑梗死的风险。

Objective To evaluate the relationship between G894T polymorphism（Glu298Asp）in the endothelial nitric oxide synthase （eNOS） gene and cerebral infarction （CI） in Chinese population. Methods All the relevant studies were identified, those unqualified studies were excluded and the publication bias was evaluated by RevMan5.1 and Statal 1.0. The Meta-analysis software（ RevMan5. 1 ） was applied for investigating the pooled OR value and 95% CI among individual studies. Results 11 articles entered the present study, including 1768 cases and 1818 controls. The pooled （ GT ＋ TF） / GG （ OR 1.46,95 % CI 1.24 - 1.73, P 〈 0. 00001 ）. The pooled TF/GG （ OR 2.18 ;95 % CI 1.32 - 3.61, P = 0. 002 ）. The pooled GT/GG（ OR1. 41;95% C1 1.18 -1.67,P=0.0001）. The pooled T/G（OR 1.65;95%C1 1.28-2.12,P= 0. 0001 ）. Conclusion G894T polymorphism（Glu298Asp） in the endothelial nitric oxide synthase（eNOS） gene is associat- ed with susceptibility of cerebral infarction in Chinese population. Genetype TT, genotype GT, and allele T increase the in- dividual susceptibility to CI respectively.