微波消解法处理明胶空心胶囊类样品的方法研究

Study on Microwave Digestion of Vacant Gelatin Capsules

目的提高微波消解法处理明胶空心胶囊类样品实验的安全性和消解效率。方法采用配有温度和压力传感器的微波消解系统对不同消解条件进行考察,优化实验方案。结果使用高比例过氧化氢参与明胶空心胶囊类样品预消解,可使后续微波消解时的压力增高变缓,最高压力下降,同时缩短实验时间,提高消解效率。结论该方法有效解决了《中国药典》方法预消解时间长和采用普通消解罐时易发生"爆罐"的问题,提高了实验安全性和方法适用性。

OBJECTIVE To assure the safety and improve the efficiency of microwave digestion of vacant gelatin capsules. METHODS Different digestion conditions were investigated by using microwave digestion system with temperature and pressure sensors to determine the optimal experimental method. RESULTS Using high proportion of hydrogen peroxide in pre-digestion could moderate the increase of pressure in microwave digestion process and at the same time shorten time and improve the digestion efficiency. CONCLUSION This method, which improves the experimental safety and applicability, is an effective way to solute the long pre-digestion time of the method of Ch. P（2010） and the burst with ordinary digestion tanks.