乳腺癌患者腋淋巴结转移与肿瘤大小及分子分型间关系的临床研究

Clinical research between axillary lymph node metastasis of breast cancer and tumor size and molecular classification

目的探讨乳腺癌患者腋窝淋巴结转移与肿瘤分子分型及肿瘤大小的关系。方法回顾性分析246例乳腺癌患者手术方式、有无腋窝淋巴结转移、转移淋巴结数目、肿瘤大小及肿瘤的分子分型。结果 246例乳腺癌患者中,术后病理证实淋巴结转移者108例。其中Luminal A型28例,淋巴结转移4例,转移率14.29%;Luminal B型156例,淋巴结转移92例,转移率58.97%;HER-2阳性型56例,淋巴结转移12例,转移率21.43%;三阴性乳腺癌(Basal-like型)6例,淋巴结均无转移。随肿瘤体积的增大,腋窝淋巴结转移率明显增高。结论乳腺癌患者腋窝淋巴结转移与肿瘤分子分型及肿瘤大小有相关性。

Objective To explore the relationship between axillary lymph nodes metastasis（ALNM） and the tumor size and molecular classification.Methods The clinical data of 246 patients of breast cancer,the surgical methods,and the axillary lymph nodes were retrospectively analysed and discussed.Results 108 cases developed axillary lymph node metastases,4 of 28 cases in Luminal A had lymph node metastases（58.97%）,and 92 of 156 cases in Luminal B had lymph node metastases（21.43%）,6 cases of Basal-like had not lymph node metastases.The bigger the tumor,the more metastases of lymph nodes.Conclusion There is relevance between axillary lymph node metastasis of breast cancer and molecular classification and the tumor size.