128层螺旋CT血管造影评估动脉粥样硬化早期斑块的实验研究

Experimental study of 128-slice CT angiography for the evaluation of early atherosclerotic plaques

目的探讨128层螺旋CT血管造影对于兔动脉粥样硬化早期斑块的诊断价值及其局限性。方法通过高脂饮食建立26只雄性新西兰大白兔的动脉粥样硬化模型,另建20只正常饲养作为对照。分别行CT血管造影检查(CTA)后,解剖家兔进行病理学对照。结果 20只正常饲养兔血管正常,CTA未见明显异常;26只高脂饮食兔的血管大体观内膜表面均布满脂纹及脂斑,CTA检查25只(96.2%)血管横断面失去正常圆滑形态,12只(46.2%)可见管壁轻度偏心性增厚,管腔狭窄不明显。结论 128层螺旋CT血管造影可以清晰显示血管形态,大范围观察全段动脉,对于早期斑块的显示主要表现为管腔形态的改变;但是也存在一定的局限性。

Objective To explore the diagnostic value and limitation of 128-slice spiral CT angiography（CTA） in the early atherosclerotic plaques on New Zealand rabbits.Methods Twenty-six New Zealand white male rabbits induced by high fat diet and twenty induced by normal diet were served as the experimental models of atherosclerosis.CTA was performed in all rabbits and the results were compared with pathological finding.Results The arteries of twenty rabbits induced by normal diet were normal;twenty-six rabbits induced by high fat diet had lipid-rich plaques overspreading the arteries.CTA showed that the arteries of twenty-five（96.2%） rabbits lost their ordinary shape,twelve rabbits（46.2%） had vessel wall off-centre thickening on small part of the images and lumen of blood vessel showed no obvious stricture.Conclusion 128-slice spiral CT angiography clearly shows the vessel,can observe the artery in a fargoing manner,and the early atherosclerotic plaques manifest the shape changing of arteries,although it has some limitations in early lesions.