酒精依赖患者注意网络研究

Attention networks in patients with alcohol dependence

目的探索酒精依赖患者注意缺陷的特征以及可能机制。方法对确诊的21例酒精依赖患者进行简易精神状态量表(MMSE)测试和注意网络测试,并与21名正常对照组相比较。结果酒精依赖患者组定向网络时间[(30.4±36.9)ms]较对照组[(56.8±22.0)ms]明显缩短;执行控制网络时间[(160.6±78.8)ms]较对照组[(103.9±47.6)ms]明显延长,差异有统计学意义(P<0.05)。而警觉网络效率与对照组的差异无统计学意义。结论酒精依赖患者定向网络和执行网络受损,提示酒精可能对额叶、顶叶等脑区有更为显著的影响。

Objective To investigate the characteristics of attention networks impairment in the patients with alcohol dependence and the impossible mechanism that the brain was harmed by the alcohol. Methods Mini - mental state examination and the attention network test were used in 21 patients with alcohol dependence and 21 normal controls. Results The orienting network function was significantly lower（P 〈 0.05） in the patients with alcohol dependence （30.4 ±36.9） ms than in normal controls （ 56.8 ±22.0） ms. The esecutive networks effects was higher（P 〈 0.05） in the patients with alcohol dependence （160.6 ±78.8）ms than in controls（56.8 ±22.0）ms. The alerting networks effects was lower in alcohol - dependent patients and in normal controls, however without significant difference （ P 〉 0.05 ）. Conclusion The orienting and executive network impairment was found in 21 patients with alcohol dependence,which suggests the frontal lobe and parietal lobe may be more significantly affected by the alcohol.