壳聚糖修饰氧化铁磁性纳米颗粒的制备和性能研究

Synthesis and characterization of chitosan modified iron oxide magnetic nanoparticles

通过共沉淀法制备氧化铁磁性纳米颗粒,用壳聚糖对其表面进行修饰得到样品(CS@MNPs);表征其形貌结构、尺寸、表面基团、表面电荷、磁学性质和在不同介质中的稳定性等。实验结果表明,CS@MNPs具有典型的立方反尖晶石晶体结构;粒径为16.5nm;在生理(pH值7.4)条件下拥有较高的正电荷(10mV);呈现超顺磁性,对驰豫时间T1、T2,尤其是T2*具有很强的响应;在双蒸馏水和含10%新生牛血清的RPMI 1640培养液中具有良好的稳定性,具有作为磁共振造影剂的潜力。

Magnetic iron oxide nanoparticles were synthesized by chemical coprecipitation and modified by chitosan（CS@MNPs）.CS@MNPs were characterized by TEM,XRD,FT-IR,VSM,zeta potential analyzer and clinical 1.5-T MR imager.It was ideally nanoparticles in medical applications own to their smaller size（16.5nm）,positive surface charge（pH 7.4）,superparamagnetic behaviour.Its relaxation time T1,T2,in particular T＊2 had a strong response by using a clinical 1.5-T MRI imager.It was well-dispersion in double distilled water and RPMI 1640 containing 10% FCS.It has demonstrated the potential to be as a MRI contrast agent.