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异丙酚预处理对过氧化氢诱导的乳鼠肝细胞凋亡的保护作用及机制

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摘要 大量研究表明,活性氧自由基(ROS)如H2O2是细胞凋亡的媒介之一,许多生物和理化因素诱导的细胞凋亡都与氧化应激(oxidative stress)密切相关[1]。细胞凋亡的调控受许多因素影响,其中p53和Bc1-2基因起着重要作用,p53是细胞凋亡的促进者,Bc1-2是细胞凋亡的抑制者。本课题拟将培养的原代乳鼠肝细胞暴露于H2O2,观察细胞凋亡的发生,
出处 《中国药物与临床》 CAS 2012年第5期595-597,共3页 Chinese Remedies & Clinics
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