热应激下脑内单胺类神经递质及其受体对运动性中枢疲劳影响的研究进展

The Effects of Monoamine Neurotransmitters and Their Receptors in the Brain on Exercise-Induced Central Fatigue under Heat Stress

乙酰胆碱(Ach)、去甲肾上腺素(NE)和5-羟色胺(5-HT)等神经递质参与下丘脑的体温调节,其受体亚型的不同也有不同的调节作用。在高温环境中,多巴胺(DA)、5-HT、NE伴随大脑和核心体温的升高而增加。提高5-HTR2活性会引起体温升高,而提高5-HTR1A活性的则会引起体温降低,DAR1、DAR2两者协同作用于体温的降低。单胺类神经递质含量改变及平衡的破坏是导致运动性中枢疲劳发生的因素之一。热应激条件下机体大脑和核心温度升高,脑内热储备过多,导致中枢疲劳的发生,提高DA、NE的活性可抑制高温介导的中枢疲劳,改善热应激下运动能力,但未能证明在高温环境下长时间运动5-HT介导疲劳的特殊作用。

Neurotransmitters such as Acetylcholine（Ach）,norepinephrine（NE） and 5-hydroxytryptamine（5-HT） regulate body temperature in the hypothalamic,the regulation of receptor lies on the difference of its subtypes.In the high temperature environment,The Concentration of dopamine（DA）,5-HT,NE Increased with the rise of brain and core body temperature.The active of 5-HTR2 increased body temperature,while The Active of 5-HTR1A reduced body temperature.In addition,DAR1 and DAR2 synergy to reduce body temperature.The changes of concetration and balance breakage in monoamine neurotransmitters is one of the important factors which caused central fatigue.The temperature of brain and core body increased in Heat stress conditions.The temperature of brain increased can cause central fatigue.The active of DA and NE Improved will inhibit central fatigue,and improve the exercise capacity under Heat stress conditions.However,5-HT can not do as DA and NE.