摘要
目的研究依达拉奉治疗病毒性心肌炎心力衰竭的效果及其抗氧自由基的作用。方法病毒性心肌炎患者41例随机分为两组。观察组给予依达拉奉治疗,对照组给予辅酶Q10治疗,观察用药前后患者心功能分级(NYHA分级),左室射血分数(LVEF)和脑利钠肽(BNP)指标变化。通过检测治疗前后血清超氧化物歧化酶(SOD)、丙二醛(MDA)了解依达拉奉的抗氧化作用。结果治疗后观察组NYHA分级(2.1±0.2)级,较对照组(2.3±0.3)级下降(P<0.05),LVEF(40.3±4.3)%较对照组(37.9±5.9)%上升(P<0.05),BNP(741±33)ng/L较对照组(1 273±38)ng/L下降(P<0.01)。依达拉奉组患者SOD活性上升高于对照组(P<0.01);MDA下降高于对照组(P<0.05)。结论依达拉奉治疗病毒性心肌炎心力衰竭临床疗效满意。
Objective To investigate the clinical effect of edaravone on viral myocarditis（VMS） complicated with heart failure and its function of antioxygen free radical.Methods Forty-one patients with VMS were randomly divided into two groups：Observation group（n=21） treated by edaravone,and control group（n=20） treated by coenzyme Q10.The cardiac function [the New York Heart Association（NYHA） classification],left ventricular ejection fraction（LVEF） and brain natriuretic peptide（BNP） were measured before and after treatment.Serum levels of superoxide dismutase（SOD） and malondialdehyde（MDA） in pts with VMS were measured before and after treatment to observe anti-oxidize effect of edaravon.Results Cardiac function was improved（P0.05）and BNP was significantly reduced（P0.01）in pts with VMS.LVEF was enhanced（P0.05）in the observation group compared with the control group.The MDA was reduced（P0.05）and activity of SOD was enhanced（P0.01） in the observation group compared with the control group.Conclusion Edaravone was effective for pts with VMS complicated with heart failure.
出处
《中西医结合心脑血管病杂志》
2012年第5期526-527,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
