长沙地区某医院血液透析患者HCV感染危险因素研究

Risk factors for hepatitis C virus infection in hemodialysis patients at a hospital in Changsha

目的了解长沙地区某医院血液透析患者丙型肝炎病毒(HCV)感染现患率以及影响HCV感染发生的危险因素。方法收集2010年1—7月在该院长期进行血液透析治疗的74例患者的一般情况和临床资料,用单因素和多因素Logistic回归分析了解其感染HCV的危险因素。结果 74例患者中,HCV抗体阳性23例,HCV感染率31.08%。单因素分析筛选出的危险因素包括血液透析持续时间、输血史、接受透析治疗医院数、每周血液透析次数;多因素分析表明,血液透析持续时间和接受透析治疗医院数是影响HCV感染发生的主要危险因素。结论血液透析持续时间和接受透析治疗医院数是血液透析患者发生HCV感染的直接危险因素。

Objective To investigate the prevalence and risk factors for hepatitis C virus（HCV） infection in hemodialysis（HD） patients at a hospital in Changsha.Methods General information and clinical data of 74 patients who received HD from January to July,2010 in a hospital were collected,univariate and multivariate Logistic regression analysis was used to analyze the risk factors for HCV infection.Results Of 74 patients,23 were HCV antibody positive,the prevalence of HCV infection was 31.08%.Univariate analysis showed that HCV infection was associated with duration of HD,history of blood transfusion,the number of hospitals offering HD,and frequency of HD per week;multivariate analysis showed that the duration of HD and the number of hospitals offering HD were major risk factors.Conclusion Duration of HD and the number of hospitals offering HD are direct risk factors for HCV infection in HD patients.