拟除虫菊酯农药暴露对婴儿生长发育的影响

Impact of pyrethroid pesticides exposure on development of one-year old infants

【目的】探讨拟除虫菊酯农药暴露对婴儿生长发育的影响,为预防儿童农药中毒提供科学依据。【方法】选取江苏某县1岁婴儿449名,收集随机尿样检测拟除虫菊酯代谢物顺式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(cis-Cl2CA)、反式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(trans-Cl2CA)和3-苯氧基苯甲酸(3-PBA)水平,测量婴儿身长、体重、头围、胸围,用"0～6岁儿童发育筛查测验"(DST)评估婴儿智能发育状况,分析两者之间关系。【结果】研究对象尿样拟除虫菊酯代谢物cis-Cl2CA、trans-Cl2CA和3-PBA检出率分别为70.4%、97.6%和84.2%。按照总拟除虫菊酯浓度P25、P75分为低中高三组,不同暴露水平组之间婴儿的体重、胸围不完全相同,具有统计学意义(P<0.05),但身长、头围和发育商差异无统计学意义。多重线性回归分析亦提示尿拟除虫菊酯的浓度与体重有相关性(P<0.05)。【结论】拟除虫菊酯暴露对婴儿体重有一定的影响。

【Objective 】 To examine associations between pyrethroid pesticides exposure and development in one-year infants.【Methods】 449 one-year old infants in a county of Jiangsu Province were studied.Their spot urine were collected and pyrethroid pesticides exposure was assessed by measuring pyrethroid metabolites（cis-Cl2CA,trans-Cl2CA and 3-PBA）.The Physical examination and the DST Scale were done and their relationship with pesticides exposure was evaluated.【Results】 Pyrethroid metabolites（cis-Cl2CA,trans-Cl2CA and 3-PBA） were found among 70.4%,97.6% and 84.2% of these infants,respectively.The weight and the chest circumference among different pyrethroid metabolites levels was significiantly different,but not the body length,the head circumference and the development quotient.The pyrethroid metabolites level was associated with a decrement in weight by using multiple liner analysis.【Conclusion】 Our findings suggest that exposure to pyrethroid negatively impacts on the weight of one-year infants.