重度失代偿性心力衰竭患者静脉注射左西孟旦治疗临床分析

目的本文主要通过对比左西孟旦和传统临床治疗心力衰竭药物的临床疗效观察左西孟旦的治疗作用以及左西孟旦的安全性等两方面。方法选取我院从2009年3月至2011年3月收治的重度失代偿性心力衰竭患者共135例。随机将患者分为观察组和对照组,2组患者均开展基础药物治疗上,观察组患者进行静脉滴注左西孟旦,对照组则采用巴酚丁胺进行静脉滴注。结果 2组患者的治疗总有效率存在有显著性的差异,观察组的治疗总有效率为81.8%明显要高于对照组患者的72.5%。患者在开展治疗后,每搏量以及射血分数均有明显的改善,但治疗组患者改善的幅度明显要比对照组患者高,2组有显著性差异(P<0.01)。药物安全性方面,观察组患者的不良反应并发率为7.58%,对照组患者不良反应率为17.4%。对照组患者的不良反应率明显高于观察组的不良反应率(P<0.01)。结论左西孟旦在治疗重度失代偿性心力衰竭能取得满意的临床效果,而且出现药物不良反应低,值得临床推广使用。

Objective This article mainly through the comparison of left West Meng Dan and traditional clinical treatment of heart failure drug clinical curative effect observation of therapeutic effects of left West Meng Dan and left West Meng Dan security from two aspects.Methods Our hospital from 2009 March to 2011 March were severe decompensated heart failure 135 cases.Patients were divided randomly into observation group and control group,two groups of patients were carried out based on drug therapy,the observation group were treated by intravenous infusion of left West Meng Dan,the control group uses the phenol butylamine,for intravenous drip.Results Two groups of patients with the total effective rate of the therapy have significant differences,the observation group was treated by total efficiency is 81.8% higher than the control group in 72.5% patients.Patients in treatment,stroke volume and ejection fraction were significantly improved,but the patients of the treatment group improved significantly than the control group patients,two had significant difference（P0.01）.Drug safety in the observation group,the adverse reaction incidence rate was 7.58%,compared to the control group patients with poor response rate of 17.4%.A control group of patients with adverse reaction rate was significantly higher than the rate of adverse reactions in observation group（P0.01）.Conclusion Left West Meng Dan in the treatment of severe decompensated heart failure can obtain satisfactory clinical results,and adverse drug reactions is low,is worthy of clinical use.