感染性疾病患者血清肌酸激酶变化分析

Analysis of serum CK level change in infectious disease patients

目的探讨感染性疾病患者血清肌酸激酶(CK)水平变化的意义及价值。方法分别测定50例细菌感染性疾病患者、43例非细菌感染性疾病患者和38例严重感染性疾病患者,所有患者均排除心血管疾病、肝功能异常、肌肉损伤、药物因素、脑损伤等可能使CK改变的因素,以及30例健康对照者的白细胞(WBC)、C反应蛋白(CRP)和CK,并监测患者治疗不同时期的CK值。结果细菌感染性疾病患者的CK明显低于非细菌感染性疾病患者和健康对照组,差异有统计学意义(P<0.01),严重细菌感染者的CK明显高于非细菌感染性疾病患者和健康对照组,差异有统计学意义(P<0.01),并且随着治疗的好转CK逐渐趋于正常。结论感染性疾病患者监测CK高低有助于早期鉴别诊断细菌感染和非细菌感染,也是鉴定严重感染程度的指标之一,同时连续监测CK可用来监测抗生素治疗效果的观察。

Objective To explore the value of serum CK level change for infectious disease patients.Methods WBC,CRP and CK were determined in 50 bacteria infectious disease patients,43 patients without bacterial infectious and 38 patients with serious infectious（All patients were ruled out of cardiovascular disease,liver function abnormal,muscle injury,drug factors,brain injury,and other possible make CK change factors） and 30 healthy controls patients.The value of CK was also monitored at the same time for patients in different treatment phase.Results The value of CK in bacterial infectious patients group was obviously lower than that in the patients infected without bacteria and the control group（P0.01）,and the value in the serious bacterial infections patients group was significantly higher than that in the patients infected without the bacteria and the control group（P0.01）.As the improvement of the illness,the value tends to normal.Conclusion It is contribute of monitoring of CK,which can make differential diagnosis between the bacterial infection and no bacteria infection early.It is one of the index that identify serious infection degree.At the same time,continuous monitoring of CK can be used to monitor antibiotic treatment effect.