摘要
黄酮类化合物不仅是一种天然的食品添加剂,而且具有抗氧化、抗菌、抗癌等活性.但因大部分天然黄酮的脂溶性或水溶性较差,致使其生物利用度较低.引入含氮基团,可有效地提高其药理活性和溶解性.综述了含氮黄酮类化合物合成的新进展.
Flavonoids are natural food additives and have antioxidant, antibacterial and anti-cancer activities and so on. However, the majority of natural flavonoids have low bioavailability because of the poor lipid solubility or water solubility. The introduction of nitrogen-containing groups can effectively improve the solubility and pharmacological activity of flavonoids. The paper summarized the progress on the synthesis of nitrogen-containing flavonoid derivatives.
出处
《河南工业大学学报（自然科学版）》
CAS
北大核心
2012年第2期83-88,94,共7页
Journal of Henan University of Technology：Natural Science Edition
基金
河南省科技攻关项目(82102330014)
郑州市科技局攻关项目(2010GYXM639)
关键词
黄酮类化合物
含氮衍生物
活性
flavonoids
nitrogen-containing derivative
activity
