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糖尿病合并血管并发症患者血CD4^+CD25^+调节性T细胞的变化及其意义 被引量：5

The changes and significances of CD4^+ CD25^+ regulatory T cells in peripheral blood of diabetic patients with angiopathy
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摘要 目的探讨CD4+CD25+调节性T细胞在2型糖尿病合并血管并发症患者免疫机制中的作用。方法用流式细胞仪检测18例2型糖尿病合并血管并发症患者、20例2型糖尿病无血管并发症患者、25例健康人血CD4+、CD8+、CD4+CD25+,计算CD4+CD25+/CD4+比值,并进行比较分析。结果糖尿病合并血管并发症组患者的CD4+CD25+调节性T细胞数量及其与CD4+比值均显著高于健康对照组(P<0.05),无血管并发症的糖尿病患者CD4+CD25+调节性T细胞数量显著少于有血管并发症的糖尿病患者(P<0.05)。结论 CD4+CD25+调节性T细胞数量及其与C4D+比值升高,可能与2型糖尿病合并血管并发症患者存在炎症反应有关。 Objective To investigate the role that CD4＋ CD25＋regulatory T cells play in the immune mechanism of type 2 diabetic patients with angiopathy.Methods CD4＋ CD25＋、CD4＋、CD8＋ of 18 patients with type 2 diabetic combined with angiopathy,20 patients of type 2 diabetic without angiopathy and 25 cases of healthy were measured by flow cytometry,and the ratio of CD4＋CD25＋/CD4＋ were caculated.The results were compared between the three groups.Results The CD4＋ CD25＋regulatory T cells counts and the ratio of CD4＋CD25＋/CD4＋ of type 2 diabetic patients with angiopathy were higher than health people（P0.05）,the CD4＋ CD25＋ regulatory T cells counts of type 2 diabetic patients without angiopathy group is lower than type 2 diabetic patients with angiopathy group（P0.05）.Conclusion The CD4＋ CD25＋regulatory T cells counts and the ratio of CD4＋CD25＋/CD4＋ in type 2 diabetic patients with angiopathy are higher than health people,may concerned with their inflammatory reactions.
作者 李洪 张志哲 李舒萍
机构地区 南宁市第一人民医院呼吸内科
出处 《内科》 2012年第2期104-106,共3页 Internal Medicine
基金 广西南宁市科学研究与技术开发计划 创新计划项目(20060168C)
关键词 2型糖尿病 血管并发症 CD4+CD25+调节性T细胞 Type 2 diabetes Angiopathy CD4＋ CD25＋regulatory T cell
分类号 R587.1 [医药卫生—内分泌]
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参考文献10

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共引文献265

同被引文献43

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引证文献5

二级引证文献16

内科
2012年 第2期

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