居室尘埃内毒素暴露与支气管哮喘及特应性疾病的关系

Relationship between the exposure of house dust endotoxin and bronchial asthma and allergic diseases

支气管哮喘(简称哮喘)与过敏性鼻炎等特应性疾病的患病率正不断上升,其发病的具体机制尚未完全清晰,主要是宿主免疫系统和环境相互作用的结果。内毒素是革兰阴性菌细胞壁上特有的结构,在外环境中内毒素几乎无处不在。内毒素对哮喘及特应性疾病而言是一把"双刃剑",早期生活暴露于内毒素可能对疾病的发展具有保护作用;然而,暴露于高水平的内毒素环境不利于疾病的控制。

Bronchial asthma （asthma） and allergic rhinitis are common allergic diseases and the prevalence of them is increasingly. The pathogenesis of asthma and atopy is not thoroughly clear. The most acceptable mechanism is the interaction of host immune system and environment. Endotoxin, being a cell wall component of Gram-negative bacteria, is ubiquitously present in our environment. Endotoxin exposure has dual effects on asthma and atopy：exposure to endotoxin in early life could he protective for the development of asthma and atopy. On the other hand, high house dust endotoxin levels are associated with worse asthma control.