慢性酒精中毒所致认知功能损害

Cognition disorders in patients with chronic alcoholism

为研究慢性酒精中毒对认知功能损害 ,将 30例慢性酒精中毒性神经病患者 ,根据每日饮酒量和饮酒史分 6组 :<2 5 0ml,2 5 0～ 5 0 0ml,>5 0 0ml;<10年 ;10～ 19年 ,>2 0年。用WAIS -RC测定其认知功能并与 30例健康者对照。结果 :2 5 0～5 0 0ml,>5 0 0ml和 11～ 19年 ,>2 0年组WAIS -RC与对照组有显著统计学差异 ,P分别 <0 0 5和 <0 0 1,<2 5 0ml和 <10年组WAIS -RC与对照组无统计学差异 ,P >0 0 5 ,提示长期大量饮酒可致认知功能损害。

To study the cognition disorders in patients with chronic alcoholism, based on the daily amount and duration of alcohol intake, 30 patients were divided into 6 groups:<250 ml,250～500 ml,>500 ml,<10 year,11～19 years and >20 years. The cognition functions of the 6 groups were evaluated using WAIS-RC and compared with 30 healthy controls.Results showed that under daily amounts 250～500 ml and >500 ml,the durations of alcohol intake 11～19 years and >20 years. Their WAIS-RC score were significantly different from the control group( P<0 05 and P<0 01 ). Of groups of daily dose <250 ml and the duration of alcohol intake<10 years,their WAIS-RC scores were not significantly different from the control group ( P>0 05 ),suggesting that long-term and high alcohol consumption can cause cognition disorders. [WT5”HZ]