运动对切除卵巢大鼠骨代谢的影响

Effect of Exercise on Bone Metabolism in Ovariectomized

目的：以组织形态计量学的方法，分析运动对切除卵巢前后大鼠骨代谢的影响，并与钙和激素进行比较。方法：切除卵巢大鼠分成正常对照组、模型组、运动组，运动十钙联合组、运动１组、运动２组、服钙组、雌激素组和制动组。检测各组骨组织形态计量学和骨密度。结果：骨组织形态计量学指标显示，运动各组的各项成骨指标最优，制动组最差，模型组、服钙组和激素组相互比较差异无显著性；实验各组骨密度测定结果显示同样的变化趋势。结论：切除卵巢前的运动可增加大鼠骨的储备量，切除卵巢后的运动可减缓大鼠骨量的丢失，有利于保持大鼠的骨量。运动作为一种简单实用的方法，对绝经后妇女的骨质疏松症可起到有效的防治作用。

Objectives: Using histomorphometry and comparing the intake of calcium and estrogen, the influence of exercise on metabolism of bone was assesed in ovariectomized rat. Metheds: Ovariectomized rats were divided into nine groups: (l)normal control;(2)osteo- porosis model; (3)exercise; (4)combination of exercise and supplement of calcium; (5)exercise after ovariectmy; (6) exercise two months after ovariectomy; (7) supplement of calcium after ovariectomy; (8)supplement of estrogen; (9)immobliization. Bone mineral density(BMD) and histomorphometry were measured and analyzed. Results:The results of bone histomorphometry showed that: the best metabolism of bone were shown in all exercise groups and the worst in immobilization group. No significant difference was shown among groups (2), (7) and(8). BMD showed the similar results as of the histomorphometry. Conclusion: exercise could slower the losing of bone mass in ovariectomezed rats, and could prevent and cure the osteoporosis effectively in menopausal women.