心理应激对不同特质焦虑运动员T淋巴细胞亚群和糖皮质激素及其受体的影响

The Effects of Psychological Stress on T-lymphocyte Subsets,Glucocorticoid and Glucocorticiid Receptor in Different Trait Anxiety Athletes

以美国马滕斯专为运动员设计的特质焦虑量表（ＳＣＡＴ－Ａ）测验为依据，测定不同心理应激对不同特质焦虑运动员Ｔ淋巴细胞及其亚群和外用血糖皮质激素（ＧＣ）及其受体（ＧＲ）的影响。结果表明：（１）高应激状态下，高焦虑组ＣＤ４＋细胞数显著减少（Ｐ＜０．０５），ＣＤ４＋／ＣＤ８＋比值显著下降（Ｐ＜０．０５）。低应激状态下高、低焦虑组无显著性差异。提示高焦虑个体在高应激后更易诱发细胞免疫功能改变。（２）基础状态下，不同特质焦虑者ＧＣ分泌没有差异，但应激后ＧＣ浓度显著升高（Ｐ＜０．０１），尤以高焦虑组为著，且与ＣＤ４＋和ＣＤ４＋／ＣＤ８＋比的改变存在相关。提示高焦虑组应激后运动员免疫功能改变与ＧＣ过量分泌有关。（３）安静状态下ＧＲ存在差异，高焦虑组ＧＲ结合位点数显著高于低焦虑组。从分子水平上解释了高焦虑人群ＨＰＡ轴为何较低焦虑人群更易被激活。

The changes in endocrine factor and their possible relationship with the changes in T - lymphocyte subsets after psychological stress were investigated in the different trait anxiety athletes. 32 subjects, male athletes, were divided into high and low trait anxiety groups by Sports Competition Anxiety Test (SCAT - A) and then each of them was randomly redivided into two subgroups, there were 8 subjects in one group. Four groups were named A, B, E, and Ft. subjects accepted responsible match with first, second and third awards arranged. Drink the experimental procedure, A and B were given a indirect suggestion, which were defined to high psychological stress, E and F named as low one without the stimulation. The results show that: (l) At the high stress condition, CD4 + numbers were significantly decreased in the high anxious group (P< 0.05), CD4 + /CD8+ ratio was descended (P< 0.05). There were no differences between the high and low anxiety groups at the low stress condition. It shows that changes of the cell immunity mainly result form high anxiety person under high stress. (2) At the normal condition, GR secretion was not different, but after the stereo, was distinctly ascended, especially in the high anxiety group. These results indicate that there are possible relationships between the changes of T - lymphocyte subsets and GC connector- tins. (3) At normal condition, GR sites were distinctly higher in high anxiety group than in low one. It means that the increase of GR sites was the factor which might make the HPA (hypothalamic - pituitary - adrenal axis) easily activated by stress in high anxiety prognoses.