KO^tBu促进的有机叠氮和末端炔烃的环加成反应改进研究

KOtBu-promoted Cycloaddition Reaction from Azides and Terminal Alkynes for Synthesis of 1,5-diaryl 1,2,3-triazoles

文章系统研究了叔丁醇钾促进下芳基叠氮和取代苯乙炔的环加成反应。在等摩尔数的叔丁醇钾作用下,当溶剂为DMF时,反应效果最佳,产率高达92%。其他的芳基叠氮和苯乙炔的反应研究结果表明,芳基叠氮和苯乙炔在此环加成反应中具有良好的反应适应性。

The reaction of phenyl azide and phenylacetylene was investigated promoted by KOtBu in DMF.Under 1.0 equiv.of KOtBu,the best result was given,and corresponding 1,5-diaryl-1,2,3-triazoles was generated.Others aromatic azides and aromatic acetylenes were suitable in the cycloaddition to construct 1,5-diaromatic 1,2,3-triazoles in good to excellent yields.