摘要
免疫脂质体作为靶向药物传递体系,以其增效减毒的特性在肿瘤诊断及治疗等领域具有独特的优势,相关研究也得到越来越多的重视。目前,免疫脂质体的制备工艺逐渐完善,选择合适的偶联方案对制剂的活性及稳定性至关重要。了解靶向分子结构及偶联反应机理有助于更好地选择修饰和连接技术,有效实现免疫脂质体靶向传递的作用。本文就免疫脂质体中抗体的类型、抗体和磷脂的修饰技术以及抗体偶联脂质体的方法进行综述。
As a targeted drug delivery system,immunoliposomes improve the therapeutic efficacy of drugs,with reduced the side effect and toxicity.The application of immunoliposomes has its unique advantage in diagnosis and therapy of tumor,related research attracts more and more attentions.A number of methods have been developed for preparing immunoliposomes,and the correct conjugation techniques for coupling antibodies to liposomes are important for the activities and stabilities of immunoliposomes.Knowledge of antibody structure and mechanism of couple reactions provides the foundation for the successful use of the modification and conjugation techniques to ensure the target delivery of immunoliposomes.This review summarizes the classification of antibodies used as target molecules,the modification of antibodies and phospholipids for conjugation and the conjugation strategies for coupling antibodies to liposomes.
出处
《药学与临床研究》
2012年第2期120-124,共5页
Pharmaceutical and Clinical Research
基金
2008年度教育部新世纪优秀人才支持计划(NCET-08-0846)
"重大新药创制"科技重大专项新制剂与新释药系统技术平台(2009ZX09310-004)
关键词
免疫脂质体
抗体
连接方案
Immunoliposomes
Antibody
Conjugation strategies
