ras p21和p53的表达与尿路上皮肿瘤临床预后的关系

Expression of Ras p21 and p53 Protein in Urothelial Tumors Correlates with Clinical Prognosis

目的 研究rasp2 1和 p5 3的表达与尿路上皮肿瘤临床及预后的关系。 方法 采用免疫组织化学ABC法检测 66例尿路上皮肿瘤rasp2 1和 p5 3的表达。 结果 rasp2 1阳性表达 40例 ( 60 .6% ) ,p5 3阳性表达 3 6例 ( 5 4.5 % ) ,rasp2 1和 p5 3共同阳性表达 2 7例 ( 4 0 .9% ) ;rasp2 1和p5 3阳性表达随肿瘤病理分级和分期的上升而增强 ,与肿瘤复发及预后呈正相关性 (P <0 .0 1)。结论 rasp2 1和 p5 3的表达可作为尿路上皮肿瘤恶性程度、浸润深度、复发和预后的重要估价指标。

Objective The study the expression of ras p21 and p53 protein in urothelial tumors and the correlation with clinical prognosis.Methods The expression of ras p21 and p53 protein was detected by immunohistochemical method in 66 cases of urothelial tumor.Results The positive rates of ras p21 and p53 were 60.6% and 54.5% respectively.The co positive rate of ras p21 and p53 was 40.9%.The positive expression of ras p21 and p53 protein increased as the rise of tumor grade and stage,and had a well correlation with higher recurrence and worse prognosis( P <0.01).Conclusion The overexpression of ras p21 and p53 have been shown to be the significant predictors for clinical prognosis of urothelial tumors.