老年肺癌组织学类型、分化及其P53蛋白表达

The Histological classification(Typing) of the elderly lung cancer patients,its differentiation and P53 protein expression

目的研究老年肺癌组织学特点及其Ｐ５３蛋白的表达。方法肺癌组织学类型按ＷＨＯ标准进行分类，Ｐ５３蛋白的表达采 用免疫组化技术。结果老年组肺癌的组织学类型与非老年组不同，差异有显著性（Ｐ＜０．０５）；Ｐ５３蛋白总阳性率为４２．８６％，两组间差 异没有显著性（Ｐ＞０．０５）。结论老年肺癌的组织学类型有其自己的特点，Ｐ５３基因在肺癌的发生发展中具有重要意义。

To study the histological features of elderly lung cancer patients and it's expression of P53 protein. Methods The histological types were determined according to WHO standard and the immunohistochemical stain was used on the expression of P53 protein. Results There were differences of the histological types between the aged and non-aged patients. The total positive rate of P53 was 42. 86 % with no statistical differences between these two groups. Conclusions the histological types of lung cancer in aged patients have their own features and P53 gene plays an important role in the progression of lung cancer.