布地奈德雾化吸入联合甲泼尼龙治疗重症支气管哮喘

Clinical Observation of Severe Bronchial Asthma Treated by aerosol inhalation of Pulmicort Respules com- bined with urbason

目的评价雾化吸入布地奈德联合小剂量甲泼尼龙治疗重症支气管哮喘的效果。方法将40例重症支气管哮喘患者采用随机数字表法分为治疗组和对照组，每组20例。治疗组予以布地奈德雾化吸入联合甲泼尼龙；对照组以甲泼尼龙治疗，观察临床效果、动脉血气及并发症情况。结果两组治疗前后组内动脉血气差异有统计学意义（P〈0．05），但两组间临床效果及治疗后动脉血气差异无统计学意义（P〉0．05），对照组并发症明显多于治疗组（P〈0．05）。结论雾化吸入布地奈德能减少全身甲泼尼龙用量，减少并发症。二者联合治疗重症支气管哮喘，能达到与单独使用大剂量甲泼尼龙相当的临床效果。

Objective To investigate the efficacy of aerosol inhalation of Pulmicort Respules combined with urbason in treating severe bronchial asthma. Methods The clinical data of 40 cases aith severe bronchial asthma treated in our hospital were analyzed retrospectively, among which 20 cases underwent Pulmicort Respules combined with urbason（Tset Group） ,20 cases underwent urbason（ Control Group）. Results Compared with the control group, the blood gas analysis in test group had statistically significant difference before treatment（ P 〈 0.05 ）. Compared with the control group, the clinical effect and the blood gas analysis in test group had no statistically significant difference after treatment （P 〉 0.05）. Compared with the control group, the complications in test group had statistically significant difference（P 〈 0.05 ）, the complications in test group was less than the control group. Conclusion Aerosol inhalation of Pulmicort Respules can reduce the mnount of urbason and lower the incidence of complications. The combination treatment of this two drugs can achieve the same clinical results alike the clinical effect of large doses of methy lprednisolone.